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It would seem that if hypertrophy of the prostate is due to atheroma, as is generally supposed, it would occur in more than 25 to 30 per cent. of all males past middle life, and I, therefore, believe that it is due entirely, or nearly so, to congestion or inflammation. Atheroma is frequent without hypertrophy, and vice versa.
Acute and subacute inflammations everywhere give rise to hyperplasia, and especially is this true in the prostate, which is abundantly supplied with blood vessels and highly cellular connective tissue. In the liver, kidney, spleen or any other glands of the body, hypertrophy or interstitial hyperplasia is always preceded by congestion or inflammation. These conclusions are the result of clinical observation and not of laboratory research. The general laws of pathology justify them.
The arteriosclerosis theory of Guyon has practically no adherents; nearly all authorities admit that congestion and inflammation will produce hyperplasia,
CROWELL AJ. THE ETIOLOGY AND TREATMENT OF HYPERTROPHY OF THE PROSTATE. JAMA. 1908;L(16):1244–1245. doi:10.1001/jama.1908.25310420012001c
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