Before the days of bacteriology, exposure to cold and wet was regarded as one of the important causative factors in tetanus, and even now it is frequently noted that such an exposure is the incident which precedes an attack of so-called idiopathic tetanus. Considerable experimental work has been done to determine what relationship exists between these phenomena, but it is only recently that any positive results have been attained.
In May, 1907, Ciuca reported to the Société de Biologie that he had been able to induce tetanus in white mice, after immersing them for a period in a freezing mixture, by injecting the spores of tetanus, freed of the toxin by exposure to heat. Vincent,1 going over the same ground, confirms this, but states that it is only after the little animals have been almost killed by the cold that tetanus may be thus induced. Vincent's results with healthy
COLD AS AN ETIOLOGIC FACTOR IN TETANUS. JAMA. 1908;L(16):1269. doi:10.1001/jama.1908.02530420037004
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