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April 25, 1908

THE OCULAR TYPHOID REACTION.PRELIMINARY REPORT OF A MODIFICATION OF THE OCULAR TEST OF CHANTEMESSE.

JAMA. 1908;L(17):1344-1345. doi:10.1001/jama.1908.25310430028001e
Abstract

On July 23, 1907, Professor Chantemesse1 announced at a meeting of the Academy of Medicine in Paris a new characteristic reaction for the diagnosis of typhoid fever. Two months later2 he published the results of this diagnostic test applied to 128 patients, together with a brief description of its method of application.

The test consisted of the instillation into the conjunctival sac of one drop of a solution made as follows: Gelatin plates covered with an 18 to 20 hour old culture of virulent typhoid bacilli were washed with 4 to 5 c.c. of sterile water. The suspension thus obtained was heated to 60 C., centrifugated and the supernatant fluid withdrawn. The centrifugated organisms were then dried and triturated. A second suspension of these broken up bacillary bodies was then made and allowed to stand for from two to three days at 60 C. The extract thus obtained

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