In 1899, Siglas saw a case of anxious melancholia, followed by mental confusion, evolve parallel with gastrointestinal autointoxication. Meyer reported five similar cases. The idea that dementia præcox is an autotoxic disease originated with Morro, who first connected hebephrenia with this cause in 1900. The evidence for its autotoxic nature may be grouped as follows: (1) There is a coincidence of certain ocular symptoms with gastrointestinal autointoxication similar, in many respects, to those seen in typhoid, lead colic, and simple intestinal putrefaction. (2) The urine in dementia præcox shows very defective elimination. (3) Fully one-half of the subjects of dementia præcox die of tuberculosis. (4) The co-existence of certain toxic dermatoses, such as certain types of erythema, vasomotor paresis, with chronic gastrointestinal intoxication, is noteworthy. (5) Some additional facts are at hand, as shown in the co-existence of psychic excesses, neurasthenia, etc., with states of autointoxication. (6) The study of
TYSON HH, CLARK LP. THE EYE SYNDROME OF DEMENTIA PRÆCOX.PRELIMINARY REPORT ON OCULAR SIGNS AND SYMPTOMS OF DEMENTIA PRÆCOX AND THEIR SIGNIFICANCE, AS OBSERVED IN 115 CONSECUTIVE CASES.. JAMA. 1908;L(18):1415–1417. doi:10.1001/jama.1908.25310440025002g
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