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Article
May 30, 1908

STANDARDIZATION OF TETANUS ANTITOXIN.

JAMA. 1908;L(22):1798-1799. doi:10.1001/jama.1908.02530480038006

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Abstract

Reference has previously been made1 to the necessity of uniformity in the strength of tetanus antitoxin and to the fact that an official standard for this preparation had recently been established in accordance with the law of July 1, 1902, regulating the sale of viruses, serums and toxins in interstate traffic. A bulletin has recently been issued by the U. S. Public Health and Marine-Hospital Service2 describing the method used in preparing this standard and its advantage as compared with European standards.

The immunity unit adopted is ten times the least amount of antitetanic serum necessary to save the life of a 350 gram guinea-pig for ninety-six hours against an official test dose of standard toxin prepared and issued by the U. S. Public Health and Marine-Hospital Service, the test dose being 100 minimal lethal doses of a precipitated toxin preserved under special conditions in the Hygienic Laboratory.

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