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June 20, 1908


JAMA. 1908;L(25):2061-2063. doi:10.1001/jama.1908.25310510029002d

Since the original articles of Wolff-Eisner, Vallée and Calmette appeared describing an inflammatory reaction of the conjunctiva following the instillation of tuberculin solutions into the conjunctival sac, a wealth of literature has accumulated in regard to the experiences of various investigators with this important test. Many that have employed the test have most enthusiastically proclaimed it simple, reliable and absolutely harmless. Unfortunately others have had less satisfactory results from its use and have stated that it is unreliable as a diagnostic measure and at all times dangerous, entailing risk of serious ocular damage.

Notwithstanding the condemnation which it has received it seems, judging from the literature, that the test is of great value and one that will be used extensively. Inasmuch as definite conclusions may be drawn only from data obtained under different conditions, I have felt it worth while to add my observations to those already recorded.

In my