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Article
June 27, 1908

THE FOLIN METHODS FOR ESTIMATING THE QUANTITY OF AMMONIA IN THE URINE.

JAMA. 1908;L(26):2134-2136. doi:10.1001/jama.1908.25310520016002a
Abstract

The growing importance of the subject of acid intoxication demands a wider knowledge of the methods of determining the ammonia in the urine. Chief among the procedures for obtaining the quantity of ammonia are those that have come from Folin's laboratory, but there are certain facts concerning them that need elucidation. Many reports in recent literature of the ammonia content of urines are made and the sole information of the means of arriving at the results is the parenthetical addition "Folin's method." On consulting some of the most modern text-books on clinical pathology, one who is not familiar with the recent literature of ammonia determinations will be much puzzled by the variation in the description of "Folin's method." For instance, in Simon's "Clinical Diagnosis," sixth edition, a certain procedure is outlined under the heading of "Folin's method;" in Hawk's "Practical Physiological Chemistry," 1907, a still different one is described, and

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