While in charge of the Laboratory of Bacteriology of the Indiana State Board of Health, in 1907, I had the opportunity of examining the brains of thirteen animals sent to the laboratory by health officers of the state. The disease from which these animals were suffering when they died or were killed was diagnosed by competent veterinarians or by physicians as hydrophobia or rabies.
In making the examinations my aim was to prove the presence or absence of Negri bodies and to note in what proportion of cases in which the bodies were found was the subdural inoculation of a rabbit or guinea-pig productive of the symptoms of rabies. My method for determining the presence of the bodies was the smear method as used and described by Williams and Lowden.1 In the preparation of these smears the technic is as follows:
A small piece of the gray matter of
RUCKER JB. THE SMEAR METHOD AS A MEANS OF THE RAPID DIAGNOSIS OF RABIES, WITH A REPORT OF THIRTEEN CASES. JAMA. 1908;LI(4):288–290. doi:10.1001/jama.1908.25410040020001f
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