Interstitial keratitis, the result of acquired syphilis, is a rare disease, if we are to judge from the number of cases reported in literature, only about one hundred cases having been reported up to date; and judging from the number of cases reported in American literature it is an extremely rare disease, only about a dozen cases having been published. Furthermore, to emphasize the extreme rarity of the reports of such cases, I may state that, so far as I have been able to ascertain, the volumes of the transactions of the American Ophthalmological Society, published first in 1864 and continuously since then, do not contain the report of a single case presented to the society, and the same is true of Knapp's Archives of Ophthalmology, begun in 1869; the American Journal of Ophthalmology, begun in 1884; Annals of Ophthalmology and Otology (now the Annals of Ophthalmology), begun in 1892,
DAVIS AE. DIFFUSE INTERSTITIAL KERATITIS IN ACQUIRED SYPHILIS.. JAMA. 1908;LI(4):292–296. doi:10.1001/jama.1908.25410040024001h
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