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August 15, 1908


JAMA. 1908;LI(7):571-572. doi:10.1001/jama.1908.25410070029001h

Among the many problems that confront the physician who would apply in practice Wright's method of therapeutic bacterial immunization is the one of mixed infection. What should be the course in case of a mixed infection? Here, as elsewhere in the practice of bacterial therapy, judgment as to the relative importance to attach to the various factors must decide the question; and it is to give the results of my quite extensive personal experience that the present communication1 is offered. In a general way it may be said that a mixed infection offers a less promising outlook than that by a single bacterial species, and still some brilliantly successful results have been obtained by inoculations in very complicated and long-standing infections.

Given two, or even three bacterial species, well known as pathogenic agents, and their simultaneous appearance in the secretion of a certain lesion, it is entirely proper to

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