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Article
September 12, 1908

A CYTOLYTIC FACTOR OCCURRING IN THE BLOOD SERUM IN MALIGNANT DISEASE.

JAMA. 1908;LI(11):915. doi:10.1001/jama.1908.25410110037002
Abstract

The following experiments were undertaken in order to ascertain the effect of prolonged exposure of cancer cells to the action of normal as well as to the patient's blood serum, the idea in mind being, on the one hand, that as the result of autoinoculation with degenerative products of the malignant growth autoantibodies of the nature of cytolysins might be formed, or on the other, that the defensive reaction of the body might find its expression inthe absence or a diminution of anti-autolytic ferments in the blood serum. That such ferments normally exist has been shown by Opie,1 among others, in the case of the leucocytes of the blood, and the same principle probably holds good for many other body cells. In the case of cancer tissue also, we could demonstrate that the mineral constituents of the blood serum play no essential rôle in the prevention of autolysis, since

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