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Article
September 12, 1908

LARGE DOSES OF ANTITOXIN IN DIPHTHERIA.REPORT OF A CASE.

JAMA. 1908;LI(11):918. doi:10.1001/jama.1908.25410110040002e

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Abstract

Although the use of antitoxin in the treatment of diphtheria is now practically universal, there is still more or less doubt as to the expediency of administering large doses after ordinary doses have failed to produce any effect. In fact, the question of dosage is the only question that remains to be answered, so far as the therapeutic use of antitoxin is concerned. The determination of the requisite dose in a given case will probably soon be reduced to some trustworthy and generally practicable method; but until that has been done our only guidance will be the experience of those who have used large doses. Toward the enrichment of the literature of that experience I wish to contribute the following mite:

History.  —On July 11, 1908, I was called to see a child, 8 years of age, who complained only of sore throat. Examination disclosed an exudate limited to the

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