This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
It appears pretty generally admitted that a secondary anemia may change to the primary pernicious type. The theory that progressive pernicious anemia is always cryptogenic was negatived when cases with the typical blood and marrow changes were demonstrated with bothriocephalus, syphilis, malaria, gastrointestinal mucosa atrophy and small pyloric cancer as precursors.
In ordinary secondary anemia the blood picture differs essentially from that of the primary type, but when in the secondary type the process reaches a point at which not only hemolysis, but deficient hematogenesis is present, the blood findings may approximate closely those of the pernicious disease. In such cases as these, in which a pathologic process sufficient to cause the anemia is problematic, but not actually demonstrated, it may take the autopsy to decide to which class the anemia actually belongs. Of course if the case is seen early enough the probability is that the change from the
TALLEY JE. THE ANEMIA OF HEPATIC CIRRHOSIS SIMULATING THE PERNICIOUS TYPE. JAMA. 1908;LI(14):1143–1144. doi:10.1001/jama.1908.25410140025002g
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: