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October 24, 1908

SUCCESSFUL CANINE INFECTION WITH CULTURES OF LEISHMANIA INFANTUM (C. NICOLLE).

JAMA. 1908;LI(17):1423-1424. doi:10.1001/jama.1908.25410170039002a

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Abstract

PRELIMINARY NOTE.  In May, 1903, Major Leishman described peculiar chromatin bodies which he found in the spleen of a patient suffering from the so-called dum-dum fever of Calcutta, and at the time he suggested the possibility of these having a trypanosomal origin. This observation was soon confirmed by Donovan and others, and consequently the so-called Leishman-Donovan bodies have come to be recognized as the cause of Kala-azar or tropical splenomegaly.In December of the same year J. H. Wright gave an accurate description of similar bodies found in the lesions of Delhi boil or Oriental sore, and like results were obtained about the same time by Marzinowsky. While, morphologically, the Wright bodies are identical with those of Leishman, there is good reason to believe that they represent distinct though related organisms.A third infection of similar type was recognized by Pianese, in Naples, in 1905. In five out of twelve

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