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November 7, 1908


JAMA. 1908;LI(19):1604. doi:10.1001/jama.1908.02540190042007

One of the most interesting of the recent contributions to our knowledge of tuberculin reactions is described in a recent article by Moro.2 Working in Pfaundler's clinic in Munich with the so-called percutaneous tuberculin reaction (rubbing in tuberculinlanolin), Moro obtained results which indicate the probable participation of the autonomic or sympathetic nervous system in the reactions. Thus in several children the ointment yielded a reaction not only at the site of application but also in a contralateral skin area situated exactly symmetrically to the spot inoculated. Again, in other children, besides the reaction at the spot anointed, scattered areas of reaction appeared in the skin at points widely separated from the inoculation site. If, for example, the tuberculin-lanolin preparation was rubbed into the skin of the abdomen, typical efflorescence appeared next day not only there but on the chest, back and neck, that is to say, in regions with