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November 21, 1908


JAMA. 1908;LI(21):1786-1787. doi:10.1001/jama.1908.02540210042009

The tendency at the moment is to assume that the substances known as hemolysins are the cause of pernicious anemia. It has long been known that grave anemias may depend on certain worm invasions, carcinoma or on atrophies of the mucous membrane of the stomach and intestines. Hemolysins can be isolated from the bodies of parasitic worms, from carcinomatous tissues and from the normal mucous membrane of the stomach and intestines and with such hemolysins anemias can be produced experimentally in animals. Similar to the action of these hemolysins is the hemolytic effect of the cobra lecithid of Kyes (a combination of lecithin with cobra poison), and Morgenroth and Reicher have produced grave anemias in animals by injection of this substance. In addition, they have made the interesting observation that if cholesterin dissolved in oil be administered to the animal simultaneously the anemia may be prevented. They assert that they