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December 19, 1908


JAMA. 1908;LI(25):2155-2156. doi:10.1001/jama.1908.25410250055002a

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The hypodermic method of administering mercury has gained a distinct and deserved place in the therapy of syphilis. Not only has the technic been gradually improved, but preparations less irritating and better suited to our needs have been produced.

For convenience of study this method readily admits of division into subcutaneous, intramuscular and intravenous injections. It is especially to the last that I desire to call attention.

The introduction of mercury (sublimate solution) by means of intravenous injections was first recommended by Bacelli in 1892, though other drugs had been administered in this way several years earlier. Two reasons have prevented this method from gaining more than limited favor with the profession; first, the delicacy of the technic; second, the fact that it is regarded by some, many of whom have never used it, as dangerous.

My experience with this method began about fifteen months ago and since then I

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