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December 19, 1908


JAMA. 1908;LI(25):2157-2158. doi:10.1001/jama.1908.25410250057002d

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Physiologic antagonism between the secretions of the ovaries and thyroid has, for some time, been in a general way recognized. Bandler very definitely attributes many of the nervous symptoms arising in adolescence and in the climacterium to "relative hyperthyroidism," by which is signified a failure of the ovaries to produce sufficient of their internal secretion to neutralize the entire product of the thyroid. Thus a condition similar to Basedow's disease is brought about, which condition is relieved by the administration of ovarin.

That the normal balance between the secretions of the thyroid and ovaries may be disturbed by a deficient thyroid secretion, thus bringing about a relative hyperthyroidism, which may be the cause of uterine hemorrhage, I have not seen stated in any of the literature at my command. The following case demonstrates that such a condition may arise:

Patient.  —Mrs. D., aged 55. Early history uneventful. Menses were established

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