The modern microbe carrier presents many interesting and difficult problems that await solution. In the case of the typhoid carrier the great question is how to rid the intestinal tract of typhoid bacilli which appear to live on there or to be eliminated by way of the intestinal contents, sometimes for remarkably long periods.
The theory has been advanced that in these cases the bacilli live on and multiply in the contents of the gall bladder whence they pass into the intestines and appear in the feces. This theory which has many facts in its favor naturally led to the idea that removal or drainage and irrigation of the gall bladder would permanently free the carrier of his bacilli. On account of the great importance of the carrier in spreading typhoid fever this would have been a most welcome solution of a problem surrounded by many and novel difficulties, but
HOW TYPHOID BACILLI MAY REACH THE GALL BLADDER. JAMA. 1909;LII(3):217. doi:10.1001/jama.1909.02540290043007
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