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In January of this year we undertook the study of erysipelas with the special consideration of the production of an artificial immunity by inoculation with a vaccine prepared from the Streptococcus erysipelatis of Fehleisen. "True" erysipelas, as you know, is due to an infection of the lymph spaces of the skin by the micro-organism just referred to, with or without involvment of subjacent cellular tissue; and the majority of investigators believe that the streptococcus of erysipelas is the sole or specific cause of the disease. Moreover, many believe that it is identical with the streptococcus causing puerperal septicemia, pyemia, etc. The work of Dean and Petruschky would seem to confirm this view.
From the standpoint of immune therapy it is a matter of some importance to discover whether the disease is one in which the bacteria are localized to the affected part or whether they commonly escape into the blood
ROSS GW, JOHNSON WJ. THE TREATMENT OF ERYSIPELAS BY INOCULATION WITH A SPECIFIC VACCINE. JAMA. 1909;LII(10):747–749. doi:10.1001/jama.1909.25420360003002
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