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Article
March 20, 1909

PERIPHERAL AND INTRACRANIAL NEUROFIBROMATOSISOR FIBROMA MOLLUSCUM, VON RECKLINGHAUSEN'S DISEASE; WITH REPORT OF A CASE

JAMA. 1909;LII(12):945-947. doi:10.1001/jama.1909.25420380011001d
Abstract

Extensive and satisfactory contributions to the literature of neurofibromatosis have been made, particularly from the pathologic standpoint, but the clinical findings in intracranial cases have not been emphasized enough, I think, to be clear even to neurologists. Textbook literature on the subject is decidedly sparse. A short survey of the literature and the summary of an almost unique, but wonderfully illustrative, case, presenting both peripheral and intracranial findings, will be of service.

Not going back to the pioneers in this field, von Recklinghausen, Knoblauch and Soyka, we find the first important work to be the monograph on neuroma by Thomson (Edinburgh, 1900). A valuable feature of his discussion is his subclassification of false neuromata into (1) diffuse and generalized fibromatosis of trunks of nerves; (2) plexiform neurofibromata; (3) cutaneous neurofibromatosis or molluscum fibrosum; (4) elephantiasis neuromatosa; (5) pigmentation of skin and nerve origin; (6) secondary malignant neuroma, being the sarcomatous

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