The careful study of fibroid tumors of the uterus in the last few years has shown that these tumors are not the benign innocuous growths they were once believed to be. Each succeeding series studied shows more clearly that the dangers of these growths are not only from the symptoms produced by the tumors themselves, such as hemorrhage, etc., but also from the complications and degenerations incident to their continued presence in the uterus.
The most important change or complication which may occur in these fibroid growths is their association with malignant changes either in the tumor itself or in its host, the uterus. This malignant change or association has a very direct bearing on the treatment of these tumors in that, if it can be proved that there is a large percentage of malignancy in the growths or dependent on their presence in the uterus, a weighty argument has
McDONALD E. FIBROMYOMA OF THE UTERUS COMPLICATED BY CANCER OR SARCOMA: WITH REPORT OF THIRTY-FIVE CASES. JAMA. 1909;LII(12):952–955. doi:10.1001/jama.1909.25420380018001g
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