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In the literature to which I have access it is stated that poisonous symptoms rarely occur with the instillation of 1 per cent. solution of atropin sulphate.
—A boy, aged 8, blond, fairly well developed and nourished, had been under treatment for interstitial keratitis since November, 1908. This was complicated with a posterior synechia in the left eye. Treatment consisted of instillations of one drop of a 1 per cent, solution of atropin sulphate five times daily with the administration of biniodid of mercury and potassium iodid internally. Six weeks ago the instillations were reduced to one drop three times daily. The general health and sight were improving.
—On Feb. 25, 1909, I was called at noon and told that the boy was acting very queerly. It was also stated that there was muscular incoordination of both lower extremities and that articulation was difficult and incoherent. I saw
FREUDENBERGER H. ATROPIN POISONING IN A CASE OF INTERSTITIAL KERATITIS. JAMA. 1909;LII(15):1181. doi:10.1001/jama.1909.25420410029002c
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