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—On Sept. 17, 1907, I was called to see Mrs. S., aged 62, who had a growth in the left breast and considerable pain. She said it had been growing for more than a year, but she had never consulted a physician about it. On examination I found the breast very large with skin adherent for some distance around the nipple area, and several thickened carcinomatous patches in the skin. The glands in the neck and axilla were much enlarged. I advised immediate operation, but the patient was opposed to this. I saw her again on Sept. 28, 1907. The pain had increased a great deal and the patient had considerable vomiting, complained of chills and had an unquenchable thirst. She had the typical cachectic color. The skin showed more thickening and discoloration. I removed the breast by the usual radical operation on October 3, removing all the glands
CRONIN JJ. TRYPSIN IN POSTOPERATIVE TREATMENT OF CARCINOMA OF BREAST. JAMA. 1909;LII(26):2103. doi:10.1001/jama.1909.25420520017003d
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