Up to a little over a hundred years ago, very scant attention was paid to pathologic conditions of the thyroid. In fact, endemic strumæ, at least in goitrous territories, were considered quite natural and even beneficial. The sporadic cases were, as a rule, confounded with tuberculous adenitis. Not until 1800, when Fodéré first described the difference between struma and cretinism, did the thyroid begin to attract any special attention.During the last century such men as Eulenberg, St. Lager, Bircher, Wollfer, Kocher and others devoted much time and labor to study of the gland. Fresh stimulus was infused into the work by the occurrence of the condition now known as "cachexia strumipriva" following complete extirpation of the thyroid; by the discovery of iodin in the gland of Bauman, and by experimental work on the organ by Cyon.In recent years the medical
WERELIUS A. EXPERIMENTAL PRESSURE ATROPHY OF THE THYROID: WITH BRIEF SUMMARY OF THE PRESENT KNOWLEDGE OF THE GLAND. JAMA. 1909;LIII(3):172–178. doi:10.1001/jama.1909.92550030007002b
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