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Our knowledge of the physiology of the hypophysis and of the symptomology of its diseases is largely a matter of recent years. It is satisfactory to know that so large a portion of it is due to work that has been, and is being, done in this country, as is shown by the Oration on Surgery by Dr. Cushing in this issue. As he says, our first insight into a possible functional activity of the gland is due to the modern comparative anatomists and embryologists and it seems a little surprising now, in the light of recent discoveries and considering the large number of castrated animals that must have been used in their investigations, that some suggestions of the function were so late in occurring to the observers. However this may be, within the last decade or two the progress has been eminently satisfactory, considering the difficulties in the way.
THE HYPOPHYSIS CEREBRI. JAMA. 1909;LIII(4):302. doi:10.1001/jama.1909.02550040054005
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