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Article
July 24, 1909

THE HARMFUL EFFECTS OF ACETANILID, ANTIPYRIN AND PHENACETIN

JAMA. 1909;LIII(4):303. doi:10.1001/jama.1909.02550040055007
Abstract

One of the most interesting and, for physicians, most instructive bulletins published by the Bureau of Chemistry at Washington has recently been issued1 on "The Harmful Effects of Acetanilid, Antipyrin and Phenacetin," by Dr. L. F. Kebler, with the collaboration of Drs. F. P. Morgan and Philip Rupp. For some time The Journal and a few other medical journals have been warning physicians of the dangers of the indiscriminate use of these valuable drugs; likewise a few of the better lay journals, among which Collier's and the Ladies' Home Journal take first rank, have carried the same warning to the public. The authors of this bulletin say regarding the raison d'être of the investigation made by the government on this subject: "The purpose of the inquiry was not to depreciate in any way the value of these substances as medicinal agents, but rather to furnish information to the public

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