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August 21, 1909

PROTEIN FEVER: THE PRODUCTION OF A CONTINUED FEVER BY REPEATED INJECTIONS OF PROTEINA PRELIMINARY NOTE

JAMA. 1909;LIII(8):629-632. doi:10.1001/jama.1909.92550080032003a

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Abstract

The purpose of this paper is to make a short preliminary report on some experiments in which we are now engaged. The work done in the hygienic laboratory of the University of Michigan during the past ten years in the study of the cleavage products of proteins, bacterial, vegetable and animal, has, in our opinion, given us quite a new point of view from which to study the infectious diseases. We have shown that all the true proteins which we have investigated, now more than thirty in kind and from diverse sources, may be split up into poisonous and non-poisonous proteins or into toxophors and haptophors. The toxophor group seems to be the same so far as its effects on animals are concerned, whatever the protein from which it is derived. Egg-white contains the same poison, physiologically at least, as that found in the typhoid bacillus, and

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