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September 25, 1909


JAMA. 1909;LIII(13):1001-1005. doi:10.1001/jama.1909.92550130001001e

Neither from the earliest collation of cases nor even from the more recent ones do we seem in a position to estimate accurately the frequency of hypophyseal tumors. The cases are reported from such widely different premises, most often according to points of special clinical significance. Thus we find it necessary to search the records of ophthalmology, treatises on acromegaly, contributions to intracranial surgery, journals devoted to radiography, and so forth, in getting at information bearing on the pathology. Mindful of this difficulty encountered in making up an exhaustive tabulation of cases, I think we may, nevertheless, assume that tumors of the hypophysis and infundibulum are quite rare.

As concerns the variety of neoplasms, we meet with simple hyperplasia, adenoma, glioma, sarcoma, carcinoma and teratoma. The teratomata of the gland are, indeed, a very rare form of tumor. Boyce and Beadles, in their large collection of cases, include three of

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