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November 6, 1909


JAMA. 1909;LIII(19):1566. doi:10.1001/jama.1909.02550190042005

Beginning with Koch's discovery of tuberculin and its use later as a diagnostic means, various attempts were made to obtain bacterial products which might be used as specific diagnostic measures. A noticeable result of these attempts was the discovery of mallein and its use in the diagnosis of glanders. More recently work has been carried out showing in several instances the diagnostic value of injections of certain dead bacteria in infections caused by those particular organisms. Of special importance in this connection seem to be the gonococcus reactions of Irons1 and the ocular typhoid reaction first described by Chantemesse and modified by Hamburger.2

In 1897 Rondot demonstrated that weak doses of potassium iodid produced, in individuals with incipient tuberculosis, reactions which were similar to those produced by tuberculin and were supposed to be caused by the liberation of tuberculin from the lesions. Later its use as a diagnostic