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December 4, 1909

THE ANALGETIC EFFECT OF LOCAL APPLICATIONS OF SOLUTIONS OF MAGNESIUM SULPHATE AND OTHER SALTS PRELIMINARY NOTE

JAMA. 1909;LIII(23):1892. doi:10.1001/jama.1909.92550230009002c
Abstract

In certain cases of cutaneous inflammation, arthritis, etc., in which I was led to make observations on the effects of external applications of magnesium sulphate, certain deep-seated pains independent of the particular affection of wdiich a patient complained, apparently disappeared in sequence—I do not say in consequence, but in sequence—of the application. In order to test whether or not this was a psychic phenomenon, other applications were made—simple saline solution, distilled water, magnesium chlorid, sodium sulphate, etc.; and, while any moist dressing in these particular cases (I am not referring now to cases in general) seemed to diminish the pain somewhat, none of them had the same decided effect as the magnesium sulphate. The nearest in such power was sodium sulphate.

As to classes of cases : One was an aneurism. A man suffering from thoracic aneurism with projection of the chest wall had some slight cutaneous irritation over the

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