Nothing in medicine is more obscure than the pathogenesis of the chronic joint disturbances which we group, in order not to commit ourselves, under the descriptive term "arthritis deformans." One of the essential causes of our ignorance concerning them is a lack of thorough and extensive study of the anatomic changes which underlie the clinical manifestations, which is undoubtedly due in large part to the difficulty one meets in obtaining any considerable quantity of material of this sort. An extensive study of material from sixty-five cases, collected during eight years by Nichols and Richardson,1 promises to clear up many of the misunderstandings and to furnish the sound anatomic basis which we must have before the etiology (and, depending on that, the therapy) can be worked out.
On account of the close relationship of the several kinds of tissues which make up the joints, it is possible for the same irritant
ARTHRITIS DEFORMANS. JAMA. 1909;LIII(23):1919–1920. doi:10.1001/jama.1909.02550230047006
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