Although we have not yet ascertained the nature of the chromaffin substance which Kohn found in the adrenals and other related organs of sympathetic origin, yet that it is of essential importance to the function of these organs is unquestionable, for its presence and quantity stand in direct relation to their functional capacity. For example, Wiesel found that in Addison's disease there was an absence or paucity of the chromaffin substance not only in the adrenals, but also in the other organs of the so-called chromaffin system. Conversely, in cases of destruction of the adrenals by malignant growths without resultant Addison's disease, it has been found that the chromaffin cells in the other organs were well supplied with their specific content, thus explaining why destruction of the adrenal had not resulted in the familiar symptom-complex of Addison's disease. These and other observations indicate that the amount of chromaffin substance present
SUDDEN DEATH DURING ANESTHESIA. JAMA. 1909;LIII(23):1920. doi:10.1001/jama.1909.02550230048007
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