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January 1, 1910

EPIDEMIC POLIOMYELITIS IN MONKEYSTHE ACTIVITY OF THE VIRUS

JAMA. 1910;LIV(1):45-46. doi:10.1001/jama.1910.92550270001001p
Abstract

In our previous communications on experimental epidemic poliomyelitis1 we described its successive transmission through two series of monkeys and discussed the nature of the virus that causes the disease. In the first place, we stated that by employing the intracerebral mode of inoculation of the virus the disease could be readily transmitted from monkey to monkey, possibly through an indefinite series, but that successive transmission could be accomplished also by means of inoculation into a large nerve (sciatic), into the circulation, the peritoneum and the subcutis. In the second place, we showed that the virus wras filterable through a Berkefeld filter and withstood glycineration. In the present article we wish to describe certain additional facts that have been ascertained concerning the virus of epidemic poliomyelitis.

The virus was shown, by inoculation experiments, to be contained in the spinal cord and brain, but it was not known whether it was present

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