Two years ago1 I published a paper on sarcoma of the long bones based on seventy-one personal observations. In this paper I gave a brief summary of the results of modern methods of treatment of sarcoma of the long bones. These results were by far the most disappointing in the whole field of modern surgery. Taking the femur for example, Butlin found 68 cases of sarcoma of the femur (subperiosteal), in which amputation at the hip-joint or just below the trochanter had been performed, and only one patient remained well beyond three years, which is sufficient proof of the practical failure of surgery alone in this condition.
In my former paper1 I proposed a new method of treatment with the hope, not only of saving more lives, but, in a certain proportion of cases, of saving the limbs as well. The number of cases so treated up to that time
COLEY WB. A PLEA FOR MORE CONSERVATIVE TREATMENT OF SARCOMA OF THE LONG BONES. JAMA. 1910;LIV(5):333–343. doi:10.1001/jama.1910.92550310001001
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