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January 29, 1910


Author Affiliations

Assistant Instructor in Surgery, University of Pennsylvania; Assistant Surgeon, Out-Patieng Department, University Hospital; Surgeon to the Children's Surgical Dispensary, Presbyterian Hospital; Surgeon to the Surgical Dispensary St. Christopher Hospital PHILADELPHIA

From the William Pepper Laboratory of Clinical Medicine of the University of Pennsylvania.

JAMA. 1910;LIV(5):362-372. doi:10.1001/jama.1910.92550310001001g

Two years ago in a contribution1 read before the Philadelphia County Medical Society on the subject of opsonins, I made the following statements: 1. "In the heralded unlimited field of therapy, where the opsonic index is ordained to play a star rôle, its utility seems destined to pass into oblivion, not only because of its inconstancy in agreement with the clinical symptomatology, but especially because of its impracticability." 2. "Although my experience thus far with artificial auto-inoculations has been most gratifying and my results in close harmony with those of other observers, I am disposed to believe that there is a tendency to overvaluation even in this method of therapy." To-day I am more than ever convinced of the correctness of that stand and I doubt very much if at present Wright himself believes, literally, his statement promulgated a few years since, that "by means of these bacterial vaccines we