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February 5, 1910

SCOPOLAMIN AND MORPHIN IN NARCOSIS AND IN CHILDBIRTH: Report to the Council on Pharmacy and Chemistry

Author Affiliations

Professor of Pharmacology, Cornell University Medical College; Member of Council on Pharmacy and Chemistry, NEW YORK CITY

JAMA. 1910;LIV(6):446-451. doi:10.1001/jama.1910.92550320009002e

The following report was submitted to the Council on Pharmacy and Chemistry of the American Medical Association, which authorized its publication. W. A. Puckner, Secretary.

E. Schmidt isolated scopolamin from several solanaceous plants and described it about ten years after Ladenburg had obtained hyoscin from the mother liquors in the manufacture of hyoscyamin. Schmidt's studies were more complete and exact than those of Ladenburg, and the name scopolamin is now applied correctly to the substance for which Schmidt first gave the true formula, C17H21N04, Ladenburg having given the formula for hyoscin, incorrectly, as C17H23N03. The term scopolamin was at first applied to levo-rotary hyoscin by Schmidt, while Hesse called the racemic form atroscin, and this term is still used commercially by Merck.

The scopolamin, or hyoscin, sold was often impure, and, since different individuals showed marked differences in reaction even to the pure substance, dependent on a variety of conditions