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February 19, 1910


JAMA. 1910;LIV(8):617. doi:10.1001/jama.1910.02550340039005

Recently we commented in these columns on the observations made by Fahr concerning the anatomic changes resulting from chronic alcoholism, which were found to be much less marked in regard to renal and vascular lesions than has been believed by most of us; although fatty changes in the liver and chronic meningeal thickening were found very frequently in the bodies of hard drinkers. An interesting supplement to the above observations is furnished by E. Bertholet1 of Lausanne, who has systematically examined the testicles of alcoholics coming to autopsy.

It has long been believed, on the basis of clinical experience and statistical evidence, that paternal alcoholism may have a considerable and deleterious influence on the offspring, Forel in particular having contended that alcoholism injures the germinative cells; he supported this view with statistics from asylums for the insane and epileptic, and gave to the alteration in the germinative cells the