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March 12, 1910

THE ELIMINATION OF HEXAMETHYLENAMIN BY THE MUCOUS MEMBRANE OF THE MIDDLE EARA PRELIMINARY NOTE: POSSIBLE APPLICATION TO THE TREATMENT OF OTITIS MEDIA

JAMA. 1910;LIV(11):871. doi:10.1001/jama.1910.92550370001001k

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Abstract

It has been known since the introduction of hexamethylenamin by Nicolaier, that the drug is eliminated in the urine partly as formaldehyd and partly unchanged, and since that time hexamethylenamin has been extensively employed as a genito-urinary antiseptic.

The discovery that it is eliminated in large amounts in the bile and cerebrospinal fluid, and that these fluids may be rendered sterile by it, we owe to Crowe, of Johns Hopkins. Many important therapeutic applications were suggested by Crowe, and based on these facts the drug has rightly assumed a position of great importance in the treatment of different pathologic states involving the biliary and meningeal tracts.

So far as I am aware, however, and so far as a cursory examination of the literature has enabled me to learn, no one has ever noted that hexamethylenamin is eliminated by the mucous membrane of the middle ear and that it

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