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March 12, 1910

Studies in Immunity.

JAMA. 1910;LIV(11):904. doi:10.1001/jama.1910.02550370074027

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When we consider that it was Bordet who discovered that the action of a bacteriolytic serum depended on the combined effect of two substances in the serum (the substances which afterward became the amboceptor and complement of Ehrlich); that he was the first to recognize the phenomenon of specific hemolysis by serums and its dependence on two substances of the same type; that he has made contributions of fundamental importance to the subjects of agglutination of bacteria, the action of antitoxins on toxins, and phagocytosis; that, with Gengou, he made certain observations on the fixation of alexin (complement) which later (in the hands of Wassermann) grew into the hemolytic or complement fixation test for syphilis; that he and Gengou have discovered what they believe to be the micro-organism of whooping-cough; and, finally, that he stands as the most prominent and most consistent opponent of the side-chain or chemical theory of

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