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March 19, 1910

Die Serodiagnose der Syphilis.

JAMA. 1910;LIV(12):1002. doi:10.1001/jama.1910.02550380082024

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Bruck's monograph is a masterly presentation of all the work done by him in collaboration with Wassermann and Neisser in developing the complement-fixation method.

The author reviews the literature on the subject up to September, 1909, and insists that all the modifications of the method are unreliable and should not be permitted to replace the original Wassermann-Neisser-Bruck technic, and he considers it essential to confine it to special institutes in the medical centers only, as has been done already in Vienna, as well as to specially trained men, to prevent the numerous possibilities of error in interpretation. The original method is described in detail. Bruck attributes all positive reactions in other diseases than syphilis, framboesia tropica and leprosy to faulty technic. The author admits that the reaction is not biologically specific, however. A positive reaction may not usually be expected before the sixth week after infection, and indicates the generalization

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