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To the Editor:
—In The Journal, March 12, there appeared an article by Dr. Barton on the excretion of the decomposition product of hexamethylenamin by the mucous membrane of the ear. After reading this article it occurred to me that if formaldehyde is excreted by the mucous membrane of the ear, possibly it is also excreted by the mucous membrane of the bronchi, and also perhaps in the alveoli of the lungs.To test this, I administered the drug to a patient with chronic bronchitis who happened to have at the time mueopurulent expectoration; after three doses, the character of the expectoration changed from mucopurulent to mucoid, arid after six doses the quantity was very much diminished. A portion of the sputum tested after three doses had been administered gave a positive reaction in a very short time. A specimen after the sixth dose also gave a positive reaction, but
Heitmuller GH. Excretion of Hexamethylenamin. JAMA. 1910;LIV(15):1222–1223. doi:10.1001/jama.1910.02550410042012
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