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In two decades the brilliant work of American surgery has developed the disease of appendicitis from a practically unknown to a well-established clinical entity. In fact, this disease has become so popular that it is now credited with almost every symptom referable to the right lower quadrant of the abdomen. For this reason many a normal appendix has been unnecessarily removed, and many other lesions in this region simulating appendicitis have been overlooked. During the past two years a clinical analysis made on cases before operation compared with the lesions found during operation has demonstrated to us the many difficulties which present themselves in the diagnosis of some of the lesions of this quadrant. This applies particularly to those cases of combined lesions of the appendix and right ureter; appendicitis simulating genitourinary disease; urinary calculi simulating appendicitis, and lesions of other organs in this region usually mistaken for appendiceal or ureteral
BROWN JY, ENGELBACH W, CARMAN RD. ANATOMIC, PATHOLOGIC AND CLINICAL STUDIES OF LESIONS INVOLVING THE APPENDIX AND RIGHT URETER: WITH SPECIAL REFERENCE TO DIAGNOSIS AND OPERATIVE TREATMENT. JAMA. 1910;LIV(19):1491–1497. doi:10.1001/jama.1910.92550450001001
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