The excretion of hexamethylenamin in the urine was reported by Nicolaier1 in 1899. The favorable results obtained from its use as a urinary antiseptic created an interest in its mode of excretion by other channels. Crowe2 has reported its excretion in the bile, pancreatic juice, cerebrospinal fluid, synovial fluid, and in the saliva and milk of dogs, and has used the drug as a prophylactic and therapeutic agent in meningitis, but particularly in gall-bladder disease due to gall-stones complicated with Bacillus typhosus. The excretion of hexamethylenamin in human milk has also been observed.3
Recently W. M. Barton4 and E. J. Brown5 have reported the use of hexamethylenamin in the treatment of otitis media and suppuration of the right antrum. The possibilities of treatment of meningitis complicated with otitis media and infections of the sinuses were suggested in Crowe's work. In Barton's case the excretion of
HANZLIK PJ. THE EXCRETION OF HEXAMETHYLENAMIN IN THE SALIVA. JAMA. 1910;LIV(24):1940. doi:10.1001/jama.1910.02550500026009
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