In 1903 Meltzer1 showed that a subcutaneous injection of epinephrin caused a marked change in a local inflammation such as is produced by inoculating cultures of Staphylococcus aureus or a drop of turpentine into the soft tissues of the rabbit's ear. The effect consists in a contraction of the actively hyperemic vessels at the periphery of the inflammatory area, while the more severely injured vessels within the inflamed focus remain unaffected. The contraction diminishes the transudation of fluid, the so-called lymph, from the hyperemic vessels, and thus reduces the local edema.
The lesions ofpoliomyelitis are associated with profound alterations of the blood-vessels, and are attended by transudation of fluid and emigration of white corpuscles from the altered vessels. The degree of vascular and interstitial changes varies in intensity in different cases and at different levels of the spinal cord. The vessels immediately within the focus of main injury are
CLARK PF. THE ACTION OF SUBDURAL INJECTIONS OF EPINEPHRIN IN EXPERIMENTAL POLIOMYELITIS. JAMA. 1912;LIX(5):367–369. doi:10.1001/jama.1912.04270080049016
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