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The third edition of this valuable book appears in an enlarged form. It discusses systematically the relation between the physiologic and therapeutic effects of substances and their chemical composition, on which, of course, are based the entire subjects of synthetic pharmaceutical chemistry and chemotherapy. An exhaustive review of the literature and an extensive bibliography, which naturally includes particularly the records of the German patent office, make this a reference work indispensable to those whose interests are along these lines, especially pharmacologists and pharmaceutic chemists. Most physicians, also, would be much enlightened by a study of the introductory chapters on the theory of the action of inorganic and organic substances, and the relation between chemical composition and physiologic effect. The author's ideas on this point may be quoted with emphatic approval: "The flood of new substances, which inventors and manufactures wish to have investigated, must cause the question to arise as
Die Arzneimittel-Synthese auf Grundlage der Beziehungen zwischen chemischen Aufbau und Wirkung. JAMA. 1912;LIX(6):468–469. doi:10.1001/jama.1912.04270080150039
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