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August 17, 1912


Author Affiliations


From the Department of Pathology, College of Physicians and Surgeons, Columbia University, Work conducted at the expense of the George Crocker Special Research Fund.

JAMA. 1912;LIX(7):517-521. doi:10.1001/jama.1912.04270080199008

An important biologic phenomenon is presented by the immunity or resistance of certain animals to the growth of transplantable tumors of white rats and mice. It may be helpful in establishing rational methods for treating human cancer if the assumption is correct that there undoubtedly exists as complete an analogy between human cancer and the tumors in these animals as the analogy between other human diseases and those that can be reproduced artificially in lower animals.

In a recent publication von Hansemann1 has again cast doubt on the analogy between human cancer and the inoculable tumors of white rats and mice, and declared that the latter are a great deal more benign in their course than human cancer. This assertion, while uttered by a man of great authority, does not coincide with the facts ascertained by a great deal of painstaking and careful experimental study. The spontaneous tumors which