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This is a summary of the history, experiment, evolution and results of the different drugs used for the original method of freezing the part to be operated on, including the use of cocain and its substitutes, so universally used at the present time. The author shows that cocain is not a safe agent for local anesthesia, but that novocain and its solution are more to be relied on. Braun has shown that the following principles are necessary for the selection of an anesthetic:
1. The locally anesthetizing effect of the drug must be less toxic than that of cocain.
2. The drug must not cause any tissue lesions.
3. It must be soluble in water, and its solutions must be sterilizable.
4. It must permit combination with suprarenal preparations. The author thinks that "novocain fulfils all of these requirements." He then enters into the discussion of the chemical composition, action
Local Anesthesia in Dentistry. JAMA. 1912;LIX(7):570. doi:10.1001/jama.1912.04270080252036
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