The practice of "overriding" the throats of chronic diphtheria-carriers with suspensions of Staphylococcus aureus was introduced by Schiotz1 in 1909. He was led to the use of Staphylococcus aureus by the observation that a patient with a sore throat due to the staphylococcus did not contract diphtheria when exposed, and also that several convalescents failed to show positive diphtheria after an attack of staphylococcus sore throat. He treated six cases with prompt disappearance of diphtheria bacilli in all of them.
Page,2 in 1911, reported the successful use of staphylococcus in one case in which the bacilli had persisted in the throat for three months after clinical recovery.
In 1911, Catlin, Scott, and Day,3 of Rockford, Ill., reported the successful use of staphylococcus in eight cases on the advice of Dr. Harris of Chicago.
Lydia M. De Witt4 has carried out an extensive series of experiments
LORENZ WF, RAVENEL MP. THE TREATMENT OF DIPHTHERIA-CARRIERS BY OVERRIDING WITH STAPHYLOCOCCUS AUREUS. JAMA. 1912;LIX(9):690–693. doi:10.1001/jama.1912.04270080372002
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