The corpus luteum of the ovary, first described by Volcherus-Coiter,1 was given its name by the celebrated anatomist, Malpighi. That it is a periodically forming body following each ovulation, and also that the corpus luteum of pregnancy is a more stable body than the ovulation corpus was recognized by Bischoff and other anatomic investigators of the first half of the nineteenth century.
Claude Bernard was the first to attribute to the ovary the function of elaborating an internal secretion. It is now fully established that the ovary does furnish a secretion which induces menstruation, maintains pregnancy during the early months, exercises a potent influence in the development of the individual, determines all the secondary sexual characteristics, i. e., the development of the breasts, the uterus, etc., and maintains with other internal secretory glands an important trophic influence on the bones, the fatty tissues and the general metabolism.
BURNAM CF. CORPUS LUTEUM EXTRACTWITH SUGGESTIONS AS TO ITS USE IN GYNECOLOGIC PRACTICE. JAMA. 1912;LIX(9):698–703. doi:10.1001/jama.1912.04270080380004
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